SY Chiou, TM Liu, HL Liu*, “Multi-User Surgical Navigation Platform Based on Mixed Reality,” IEEE Access, 99, 1-18, Nov. 2024
TH Hsieh*, PC Chu, TXD Nguyen, CW Kuo,PK Chang, KHS Chen, HL Liu*, “Neuromodulatory Responses Elicited by Intermittent Versus Continuous Transcranial Focused Ultrasound Stimulation of the Motor Cortex in Rats,” International Journal of Molecular Sciences, 25, 5687-5701, Sept. 2024
PC Chu, HY Yu, R. S. Fisher, HL Liu*, “Neuromodulatory focused ultrasound for epilepsy: Are animal models useful?,” ACS Chemical Neuroscience, 15, 1728-1731, May 2024
AH Liao, CH Wang, CY Wang, HL Liu, HC Chuang, WJ Tseng, CP Shih, PH Tsui, “Computer-aided diagnosis of Duchenne muscular dystrophy based on texture pattern recognition on ultrasound images using unsupervised clustering algorithms and deep learning,” Ultrasound in Medicine & Biology, 50, 1058-1068, Mar. 2024
CY Huang, JC Li, KT Chen, YJ Lin, LY Feng, HL Liu*, KC Wei*, “, “Evaluation the Effect of Sonodynamic Therapy with 5-Aminolevulinic Acid and Sodium Fluorescein by Preclinical Animal Study,” Cancers, 16, 1-11, Jan. 2024
TXD Nguyen, CW Kuo, CW Peng, HL Liu, MY Chang, TH Hsieh, “Transcranial Burst Electrical Stimulation Contributes to Neuromodulatory Effects in the Rat Motor Cortex ,” Frontiers in Neuroscience, Vol. 17, pp1-11, Aug. 2023
KT Chen, CY Huang, PC Pai, WC Yang, CK Tseng, HCh Tsai, SY Lin, JC Lin, CC Chuang, PW Hsu, CC Lee, YJ Lin, CH Toh, HL Liu*, KC Wei*, “Focused ultrasound combined with radiotherapy for malignant brain tumor: Preclinical and clinical study ,” Journal of Neuro-Oncology, Vol. 165, pages 535–545, Jul. 2023
SY Chiou, LS Liu, CW Lee, DH Kim, MA Al-masni, HL Liu, KC Wei, JL Yan, PY Chen, “Augmented Reality Surgical Navigation System Integrated with Deep Learning,” Bioengineering, Vol.10, No. 617, pp1-18, May 2023
PC Chu, CS Huang, SZ Ing, HY Yu, R.S. Fisher, HL Liu*, “Pulsed Focused Ultrasound Reduces Hippocampal Volume Loss and Improves Behavioral Performance in the Kainic Acid Rat Model of Epilepsy,” Neurotherapeutics, Vol. 20, pp502-517, Mar. 2023
PC Chu, CS Huang, PK Chang, RS Chen, KT Chen TH Hsieh*, HL Liu*, “Weak Ultrasound Contributes to Neuromodulatory Effects in the Rat Motor Cortex,” International Journal of Molecular Sciences,, Vol. 24, No. 3, Issue.2578, 1-9, Jan. 2023
IC Lee, YC Lin, HL Liu, NC Liu, “Dual-Frequency Ultrasound Enhances Functional Neuron Differentiation from Neural Stem Cells by Modulating Ca2+ Dynamics and the ERK1/2 Signaling Pathway,” Journal of Cellular Physiology, Vol. 238, No. 1, pp. 137-150, May 2022
SY Chiou, ZY Zhang, HL Liu, JL Yan, KC Wei, PY Chen, “Augmented reality surgical navigation system for EVD,” Healthcare, Vol.10, No. 10, 1-9, Apr. 2022
TN Hoang, HC Lin, CH Tsai, CK Jan, HL Liu*, “Passive Cavitation Enhancement Mapping via An Ultrasound Dual-Mode Phased Array to Monitor Blood-Brain Barrier Opening,” Journal of Medical and Biological Engineering, Vol. 42, pp. 757–766, Mar. 2022
PC Chu, HY Yu, CC Lee, R Fisher*, HL Liu*, “Pulsed Focused Ultrasound Provides Long-Term Suppression of Epileptiform Bursts in the Kainic Acid-Induced Epilepsy Rat Model,” Neurotherapeutics, Vol.19, No.4 , pp.1368-1380, Feb. 2022
CY Lin, CY Huang, CM Chen, HL Liu, “Ultrasound-Stimulated Alpha-Synuclein Expression leads to Dopamine Neuron-Deficit Characteristic Models for Parkinson’s Disease,” Pharmaceutics, Vol. 14, No. 444, 1-14, Jan. 2022
TH Hsieh, XK He, HH Liu, JJ Chen, CW Peng, HL Liu, YZ Huang, “A Rotenberg, KT Chen, MY Chang, YH Chiang, PK Chang, CW Kuo, “Early repetitive transcranial magnetic stimulation exerts neuroprotective effects and improves motor functions in hemiparkinsonian rats,” Neural Plasticity, Vol. 2021, 1-16, Aug. 2021
CC Lee, CC Chou, FJ Hsiao, YH Chen, CF Lin, CJ Chen, SJ Peng, HL Liu, HY Yu, Science Eurkalert news release)., “A Pilot Study of Focused Ultrasound for Drug-Resistant Epilepsy,” Epilepsia, Vol. 63, No. 1, 162-175, Jul. 2021
YJ Ho, CC Huang, CH Fan, HL Liu*, CK Yeh*, “Ultrasonic Technologies in Imaging and Drug Delivery,” Cellular and Molecular Life Sciences, 1-20, Jun. 2021
KT Chen, KC Wei, HL Liu*, “Focused Ultrasound Combined with Microbubbles in Central Nervous System Applications,” Pharmaceutics , 1084, 1-20, May 2021
S Fadera, PY Chen, HL Liu*, IC Lee*, “Induction Therapy of Retinoic acid with a TMZ-loaded Gold Nanoparticle-Associated Ultrasound Effect on Glioblastoma Cancer Stem-like Colonies,” ACS Applied Materials & Interfaces, pp. 1-11 2021 , 1-21, Mar. 2021
KT Chen, WY Chai, YJ Lin, CJ Lin, PY Chen, HC Tsai, CY Huang, J Kuo, HL Liu*, KC Wei*, “Neuronavigation-Guided Focused Ultrasound for Transcranial Blood-Brain-Barrier Opening and Immunostimulation in Brain Tumors,” Science Advances, Vol. 7, 1-13, Jan. 2021
WH Liao, MY Hsiao, Y Kung, HL Liu, JC Béra, C Inserra, WS Chen, “TRPV4 promotes acoustic wave-mediated BBB opening via Ca2+/PKC- pathway,” Journal of Advanced Research, Vol. 26, No.2020,, 15-28, Sept. 2020
Y Kung, HY Huang, WH Liao,AP Huang, MY Hsiao, CH Wu, HL Liu, C Inserra and WS Chen, “A Single High-Intensity Shock Wave Pulse With Microbubbles Opens the Blood-Brain Barrier in Rats,” Frontiers in Bioengineering and Biotechnology, Vol. 8, 42, 1-16, Aug. 2020
YJ Ho, JP Li, CH Fan, HL Liu*, CK Yeh*, “Ultrasound in Tumor Immunotherapy: Current Status and Future Developments,” Journal of Controlled Release, Vol. 323, 12-23, Jul. 2020
K Yang, Q Li, HL Liu, CK Chen, CW Huang, JR Chen, YW Tsai, Z Zhou, PH Tsui, “Frequency-domain CBE imaging for ultrasound localization of the HIFU focal spot: a feasibility study,” Scientific Reports, Vol. 10, No. 1:5468, 1-12, May 2020
CY Lin, CH Tsai, YC Lin, CY Huang, SR Wu, CM Chen, Hao-Li Liu*, “Ultrasound-Responsive Neurotrophic Factor-Loaded Microbubble-Liposome Complex: Preclinical Investigation for Parkinson's Disease Treatment,” Journal of Controlled Release, Vol. 321, 519-528, Mar. 2020
SG Chen, CH Tsai, CJ Lin, CC Lee, HY Yu, TH Hsieh, HL Liu*,, “Transcranial focused ultrasound pulsation suppresses pentylenetetrazol induced epilepsy in vivo,” Brain Stimulation, Vol. 13, 35-46, Jan. 2020
AH Liao, KH Lin, HC Chuang, CH Tsai, YC Lin, CH Wang, CP Shih, and HL Liu*, “Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement,” Scientific Reports, Vol. 10, No. 1:4338, 1-12, Jan. 2020
CH Wu, HL Liu, CT Ho, PH Hsu, CH Fan, CK Yeh, ST Kang, WS Chen, FN Wang, HH Peng, “Monitoring of acoustic cavitation in microbubble-presented focused ultrasound exposure using gradient-echo magnetic resonance imaging,,” Journal of Magnetic Resonance Imaging, Vol. 51, No. 1, 311-318, 2020
KT Chen, KC Wei and HL Liu*, “Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment,” Frontiers in Pharmacology, Vol. 10, 1-16, 2019
CY Lin, CH Tsai, LY Feng, WY Chai, CJ Lin, CY Huang, KC Wei, CK Yeh, CM Chen, HL Liu*, “Focused Ultrasound-Induced Blood Brain-Barrier Opening Enhanced Vascular Permeability for GDNF Delivery in Huntington's Disease Mouse Model,” Brain Stimulation, Vol. 12, No. 5, 1143-1150, 2019
CJ Lin, CY Lin, YT Lin, CY Huang, KC Wei, JC Chen, GJL Chen, HL Liu*, “Microbubble-Facilitated Ultrasound Pulsation Promotes Direct α-Synuclein Gene Delivery,” Biochemical and Biophysical Research Communications, Vol. 517, No. 1, 77-83, 2019
IC Lee, ab S Faderaa, HL Liu*, “Strategy of differentiation therapy: effect of dual-frequency ultrasound on the induction of liver cancer stem-like cells on a HA-based multilayer film system,” Journal of Materials Chemistry B, Vol. 7, No. 35, 5401-5411, 2019
A Rotenberg, CH Juan, YC Pei, HL Liu, XJ Feng, YZ Huang, TH Hsieh, YH Chiang and JY Wang,, “Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats,” Neural Plasticity, Vol. 2019: 4252923, 1-11, 2019
C Cornua, M Guédraa, J-C Béraa, HL Liu, WS Chen, C Inserraa, “Ultrafast monitoring and control of subharmonic emissions of an unseeded bubble cloud during pulsed sonication,,” Ultrasonics Sonochemistry, Vol.42, 697-703, 2018
MT Tsai, JW Zhang, KC Wei, CK Yeh, HL Liu*, “Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography,” Biomedical Optics Express, Vol. 9, No. 2, 507-517, 2018
Y Kung, C Lan, MY Hsiao, MK Sun, YH Hsu, APH Liao, WH Liao, HL Liu, C Inserra, WS Chen, “Focused shockwave induced blood-brain barrier opening and transfection,,” Scientific Reports, Vol. 2218, 1-12, 2018
ZH Zhou, SC Wu, MY Lin, J Fang, HL Liu*, and PH Tsui*, “Three-dimensional visualization of ultrasound backscatter statistics by window-modulated compounding Nakagami imaging,” Ultrasonic Imaging, Vol. 40, No. 3 , 171-189, 2018
WY Chai, PC Chu, CH Tsai, CY Lin, HW Yang, HY Lai, HL Liu*, “Image-Guided Focused-Ultrasound CNS Molecular Delivery: An Implementation via Dynamic Contrast-Enhanced Magnetic-Resonance Imaging,” Scientific Reports, Vol. 8:4151, 1-12, 2018
CH Tsai, KT Chen, YX Lin, YC Lin, WS Chen, C Inserra, and HL Liu*,, “Acoustic Emission-Feedback Planar Ultrasound System for Localized Blood-Brain Barrier Opening Monitoring,” Journal of Medical and Biological Engineering, Vol. 39, No. 3, 277-286, 2018
SM Huang, HL Liu, DW Li, and ML Li,, “Ultrasonic Nakagami Imaging of High-intensity Focused Ultrasound-Induced Thermal Lesions in Porcine Livers: Ex Vivo Study,” Ultrasonic Imaging, Vol. 40, No. 5, 310-324, 2018
HL Liu*, CH Tsai, CK Jan, HY Chang, SM Huang, ML Li, W Qiu, H Zheng, “Design and Implementation of a Dual-Transmit/Receive-Mode Therapeutic Ultrasound Phased Array System for Brain Therapy,,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 65 , No. 10, 1756 -1767, 2018
HC Tsai, CH Tsai, WS Chen, C Inserra, KC Wei, HL Liu*, “Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening,” Scientific Reports, Vol. 8 , 1-13, 2018
IC Lee, HJ Wu, HL Liu*, “Dual-frequency ultrasound induces neural stem/progenitor cell differentiation and growth factor utilization by enhancing stable cavitation,” ACS Chemical Neuroscience, Vol. 10, 1-18, 2018
HH Peng, CH Wu, ST Kang, JW Zhang, HL Liu, WS Chen, CH Wang, CK Yeh, “Real-Time Monitoring of Inertial Cavitation Effects of Microbubbles by Using MRI: In Vitro Experiments,” Vol. 77, No. 1, Magnetic Resonance in Medicine, 102-111, 2017
P Rwei, CSA Gong, LJ Luo, MB Lin, JY Lai*, HL Liu*, , “In vitro investigation of ultrasound-induced oxidative stress on human lens epithelial cells,,” Biochemical and Biophysical Research Communications, Vol. 482, 954-960, 2017
PY Chen, CK Yeh, PH Hsu, CY Lin, CY Huang, KC Wei, HL Liu*, “Drug-carrying Microbubbles as a Theranostic Tool in Convection-Enhanced Delivery for Brain Tumor Therapy,” Oncotarget, Vol. 8, No. 26, 42359-42371, 2017
SK Wu, PC Chu, WY Chai, ST Kang, CH Tsai, CH Fan, CK Yeh, HL Liu*, , “Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening,” Scientific Reports, No. 7, 46689, 2017
Lee, JC Yeh, CH Tsai, JT Yang, SL Lou, CJ Seak, CY Wang, KC Wei, HL Liu*, “mproved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat,” Scientific Reports, Vol. 7, No. 1, 1638, 2017
CH Fan, CY Lin, HL Liu*, and CK Yeh*, “Ultrasound Targeted CNS Gene Delivery for Parkinson’s Disease Treatment,” Journal of Controlled Release, Vol. 261, 246-262, 2017
FCM Wu, WH Hsu, HL Liu, T Yonezawa,A Balcytis, S Juodkazis,and K Hatanaka, “Photoacoustic signal enhancements from gold nano-colloidal suspensions excited by a pair of polarized time-delayed femtosecond pulses,” Optics Express, Vol. 25, 19497-19507, 2017
J Xia, PH Tsui, HL Liu*, “Low-Pressure Burst-Mode Focused Ultrasound Wave Reconstruction and Mapping for Blood-Brain Barrier Opening: A Preclinical Examination,,” Scientific Reports, No. 6, 27939, 2016
FCP Masim, HL Liu, M Porta, T Yonezawa, A Balcytis, S Juodkazis, WH Hsu, and K Hatanaka, “Enhanced photoacoustics from gold nano-colloidal suspensions under femtosecond laser excitation,” Optics Express, Vol. 24, No. 13, 14781-14792, 2016
FCP Masim, WH Hsu, CH Tsai, HL Liu, M Porta, MT Nguyen, T Yonezawa, A Balcytis, X Wang, S Juodkazis, and K Hatanaka, “MHz-ultrasound generation by chirped femtosecond laser pulses from gold nano-colloidal dispersions,” Optics Express, Vol. 24, No. 15, 24050-24059, 2016
PC Chu, Wen-Yen Chai, CH Tsai, ST Kang, CK Yeh and HL Liu*, “Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging,” Scientific Reports, No. 6, 33264, 2016
MT Tsai, IC Lee, ZF Lee, HL Liu, YC Choia, CC Wang, JD Lee1*, “In vivo evaluation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence imaging,” Biomedical Optics Express, Vol. 7, No. 5,, 1865-1876, 2016
CH Fan, YH Cheng, CY Ting, YJ Ho, PH Hsu, HL Liu*, CK Yeh*, “Ultrasound/Magnetic Targeting with SPIO-DOX-Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors,” Theranostics, Vol. 6, No. 10, 1542-1556, 2016
SS Li, CW Lin, KC Wei, CY Huang, PH Hsu, HL Liu, YJ Lu, SC Lin, HW Yang*, CCM Ma*, “Non-invasive screening for early Alzheimer's disease diagnosis by a sensitively immunomagnetic biosensor,” Scientific Reports, No. 6, 25155, 2016
CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai, CY Huang, MY Hua, KC Wei, CK Yeh, and HL Liu*,, “Non-invasive, Neuron-Specific Gene Therapy by Focused Ultrasound-Induced Blood-Brain Barrier Opening in Parkinson’s Disease Mouse Model,” Journal of Controlled Release, Vol. 235, 72-81, 2016
YW Chen, TY Liu, PH Chang, PH Hsu, HL Liu, HC Lin, SY Chen, “A theranostic nrGO@MSN-ION nanocarrier developed to enhance the combination effect of sonodynamic therapy and ultrasound hyperthermia for treating tumor,” Nanoscale, Vol. 8, No. 25, 12648-12657, 2016
HY Huang**, HL Liu**, PH Hsu, CS Chiang, CH Tsai, HS Chi, SY Chen, and YY Chen*, “Multitheragnostic Nanobubble System to Induce Brain-Blood Barrier Disruption with Magnetically Guided Focused Ultrasound,” Advanced Materials, Vol. 27, 655-661, 2015
CH Fan, CY Ting, YC Chang, KC Wei, HL Liu*, and CK Yeh*, “Drug-loaded Bubbles with Matched Focused Ultrasound Excitation for Concurrent Blood-Brain Barrier Opening and Brain-Tumor Drug Delivery,” Acta Biomaterialia, Vol. 15, 89-101, 2015
PY Chen, HY Hsieh, CY Huang, CY Lin, KC Wei, and HL Liu*, “Focused Ultrasound-Induced Blood-Brain Barrier Opening to Enhance Interleukin-12 Delivery for Brain Tumor Immunotherapy: A Preclinical Feasibility Study,” Journal of Translational Medicine, Vol. 13, No. 93, 1-12, 2015
CY Lin, HY Hsieh, WG Pitt, CY Huang, IC Tseng, CK Yeh, KC Wei, HL Liu*, “Focused Ultrasound-Induced Blood-Brain Barrier Opening for Non-Viral, Non-invasive, and Targeted Gene Delivery,” Journal of Controlled Release, Vol. 21, 1-9, 2015
PC Chu**, HL Liu**, HY Lai, CY Lin, HC Tsai, YC Pei,, “Neuromodulation accompanying focused ultrasound-induced blood-brain barrier opening,” Scientific Reports, Vol. 5, 15477, 2015
HW Yang, CY Huang, CW Lin, HL Liu, CW Huang, SS Liao, PY Chen, PW Hsu, YJ Lu, KC Wei, CCM Ma, “Gadolinium-functionalized nanographene oxide as a nanocarrier for combined drug and microRNA delivery and magnetic resonance imaging,” Biomaterials, Vol., 35, No. -42, 6534-6542, 2014
HL Liu, CH Fan, CY Ting, and CK Yeh, “Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors,” Theranostics, Vol. 4, No. 4, 432-444, 2014
HL Liu*, CK Jan, PC Chu, JC Hong, PY Lee, JD Hsu, CC Lin, CY Huang, PY Chen, and KC Wei*, “Design and Experimental Evaluation of a 256-Channel Dual-Frequency Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Opening and Brain Drug Delivery,” IEEE Transactions on Biomedical Engineering, Vol. 61, No. 4, 1350-1360, 2014
X Geng, Z Zhou, Q Li, S Wu, CY Wang, HL Liu, CC Chuang, and PH Tsui, “Comparison of ultrasound temperature imaging with infrared thermometry during radio frequency ablation,” Japanese Journal of Applied Physics,” Vol. 53, No. 4, 047001, 2014
CH Fan**, HL Liu**, CY Ting, YH Lee, CY Huang, YJ Ma, KC Wei, TC Yen and CK Yeh, “Submicron-Bubble-Enhanced Focused Ultrasound for Blood–Brain Barrier Disruption and Improved CNS Drug Delivery,” PLoS ONE, Vol.9, No. 5, e96327, 2014
J Xia, Q Li,PY Chen, Z Zhou,CY Wang, HL Liu, J Teng, and PH Tsui, “Considering Angle Selection When Using Ultrasound Electrode Displacement Elastography to Evaluate Radiofrequency Ablation of Tissues,” BioMed Research International,, Vol 2014, 764320, 2014
WY Chai, PC Chu, MY Tsai, YC Lin, JJ Wang, KC Wei, YY Wai and HL Liu*, “Magnetic-Resonance Imaging for Kinetic Analysis of Permeability Changes during Focused Ultrasound-Induced Blood-Brain Barrier Opening and Brain Drug Delivery,” Journal of Controlled Release, Vol. 192, 1-9, 2014
CH Fan, WH Lin, CY Ting, WY Chai, TC Yen, HL Liu* and CK Yeh*, “Contrast-Enhanced Ultrasound Imaging for the Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening,” Theranostics, Vol. 4, No. 10, 1014-1025, 2014
MT Tsai, FY Chang, CK Lee, CS Gong, YX Lin, JD Lee, CH Yang, HL Liu*, “Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography,” Biomedical Optics Express, Vol. 5, No. 7, 2009-2022, 2014
KJ Chen, EY Chaung, SP Wey, KJ Lin, F Cheng, CC Lin, HL Liu, HW Tseng, CP L, MC W, CM Liu, and HW Sung, “Hyperthermia-Mediated Local Drug Delivery by a Bubble-Generating Liposomal System for Tumor-Specific Chemotherapy,,” ACS Nano, Vol. 8, No. 5, 5105-5115, 2014
HL Liu*, CY Huang, JY Chen, HYJ Wang, PY Chen, and KC Wei, “Pharmacodynamic and Therapeutic Investigation of Focused Ultrasound-induced Blood-Brain Barrier Opening for Enhanced Temozolomide Delivery in Glioma Treatment,” PLoS ONE, Vol. 9, No. 12, e114311, 2014
AH Liao, HY Chou, YL Hsieh, SC Hsu, KC Wei, and HL Liu*, “Enhanced Therapeutic Epidermal growth factor receptor (EGFR) Antibody Delivery via Pulsed Ultrasound with Targeting Microbubbles for Glioma Treatment,” Journal of Medical and Biological Engineering, Vol. 1, pp. 1-9, 1-11, 2014
PY Chen, KC Wei, HL Liu*, “Neural Immune Modulation and Immunotherapy Assisted by Focused Ultrasound Induced Blood-Brain Barrier Opening,” Human Vaccines & Immunotherapeutics, Vol. 11, no. 10, 1-11, 2014
K-C Wei, H-C Tsai, Y-J Lu, H-W Yang, M-Y Hua, M-F Wu, P-Y Chen, C-Y Huang, T-C Yen, and H-L Liu*, “Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine,” American Journal of Neuroradiology, Vol. 34, No. 1, 115-120, 2013
KC Wei, PC Chu, HYJ Wang, CY Huang, PY Chen, HC Tsai, YJ Lu, IC Tseng, PY Lee, TC Yen, and HL Liu*,, “Focused Ultrasound-induced Blood–Brain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment: A Preclinical Study,,” PLoS ONE, Vol. 8, No. 3, e58995, 2013
PC Chu, WY Chai, HY Hsieh, JJ Wang, SP Wey, CY Huang, KC Wei and HL Liu*, “Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors,” BioMed Research International, Vol. 2013, 627496, 2013
HW Yang, HL Liu**, ML Li, IW Hsi, CT Fan, CY Huang, YJ Lu, MY Hua, HY Chou, JW Liaw, CCM Ma and KC Wei, “Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy,” Biomaterials,, Vol. 34, 5651-5660, 2013
CY Wang, TS Yeh, XN Geng, HL Liu, and PH Tsui, “Monitoring Radiofrequency Ablation with Ultrasound Nakagami Imaging,” Medical Physics, Vol.40, No.7, 072901, 2013
MT Tsai, CK Lee, KM Lin, YX Lin, TH Lin, TC Chang and HL Liu*, “Quantitative Observation Evaluation of Focused Ultrasound Induced Vascular Leakage and Deformation after Focused Ultrasound Treatment Exposure via by using Fluorescein Angiography and Optical Coherence Tomography,” Journal of Biomedical Optics, Vol.18, No. 10, 101307, 2013
YW Huang, SH Hu, SY Hung, CS Chiang, HL Liu, TL Chiou, HY Lai, YY Chen,, “SPIO Nanoparticle-Stabilized Nanobubbles with MR/US Dual-Modality Imaging and HIFU-triggered Release Drug for in-vivo Therapy,” Journal of Controlled Release, Vol. 172 , 118-127, 2013
JJ Xia, Q Li, HL Liu, WS Chen and PH Tsui, “An Approach for the Visualization of Temperature Distribution in Tissues According to Changes in Ultrasonic Backscattered Energy,” Computational and Mathematical Methods in Medicine, Vol 2013, 682827, 2013
C-Y Ting, C-H Fan, H-L Liu*, C-Y Huang, H-Y Hsieh, T-C Yen, K-C Wei, C-K Yeh*,, “Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment,” Biomaterials, Vol. 33, 704-712, 2012
H-L Liu, H-W Yang, M-Y Hua, and K-C Wei, “Enhanced Therapeutic Agent Delivery via MRI-Monitored Focused Ultrasound Blood-Brain Barrier Disruption for Brain Tumor Treatment: An Overview of the current Preclinical Status,” Neurosurgical Focus, Vol. 32, No. 1, 1-11, 2012
Y-C Lin, T-H Chan, C-Y Chi, S-H Ng, H-L Liu, K-C Wei, Y-Y Wei, C-C Wang, J-J Wang, “Blind Estimation of Arterial Input Function in Dynamic Contrast-Enhanced MRI using Purity Maximization,” Magnetic Resonance in Medicine, Vol. 68, No. 5, 1439-1449, 2012
H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, C-K Chuang, P-C Chu,P-Y Wu, Y-H Chang, H-C Chuang, K-J Yu, and S-T Pang, “Cooperative dual-activity targeted nanomedicine for specific and effective prostate cancer therapy,” ACS Nano, Vol.6, No. 2, 1795-1805, 2012
P-H Tsui, Y-T Chien, H-L Liu, Y-C Shu, W-S Chen,, “Using ultrasound CBE imaging without echo shift compensation for temperature estimation,” Ultrasonics, Vol. 52, No. 7, 925-935, 2012
C-H Fan, H-L Liu, C-Y Huang, Y-J Ma, T-C Yen, C-K Yeh, “Detection of intracerebral hemorrhage and transient blood-supply shortage in focused ultrasound-induced blood-brain-barrier disruption by ultrasound imaging,” Ultrasound in Medicine and Biology, Vol. 38, No. 8, 1372-1382, 2012
P-H Wang**, H-L Liu**, P-H Hsu, C-R C Wang, P-Y Chen, K-C Wei, T-C Yen, and M-L Li, “Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused- ultrasound induced blood-brain barrier opening in a rat model,” Journal of Biomedical Optics, Vol. 17, No. 6, 1-7, 2012
P-H Tsui, Y-C Shu, W-S Chen, H-L Liu, I-T Hsiao, and Y-T Chien, “Ultrasound temperature estimation based on probability variation of backscatter data,” Medical Physics, Vol. 39, No. 5, 2369-2385, 2012
A-H Liao, H-L Liu**, C-H Su, M-Y Hua, H-W Yang, Y-T Weng, P-H Hsu, S-M Huang, S-Y Wu, H-El Wang, T-C Yen and P-C Li, “Paramagnetic Perfluorocarbon-Filled Albumin-(Gd-DTPA) Microbubbles for the Induction of Focused-Ultrasound-Induced Blood–Brain Barrier Opening and Concurrent MR and Ultrasound Imaging,” Physics in Medicine and Biology, Vol. 57, 2787-2802, 2012
Y-H Ma, S-Y Chen, S-J Tu, H-W Yang, H-L Liu, “Manipulation of magnetic nanoparticle retention and hemodynamic consequences in microcirculation: assessment by laser speckle imaging,” International Journal of Nanomedicine, Vol. 7, 1-11, 2012
P-H Liao, H-H Yang, P-T Chou, M-H Wang, P-C Ju, H-L Liu, and L-K Chen, “Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats,” Journal of Biomedical Sciences, Vol. 19, 1-12, 2012
A-H Liao, Y-K Li, W-J Lee, M-F Wu, H-L Liu, and M-L Kuo, “Estimating the Delivery Efficiency of Drug-Loaded Microbubbles in Cancer Cells with Ultrasound and Bioluminescence Imaging,” Ultrasound in Medicine and Biology, Vol. 38, No. 11, 1938-1948, 2012
H-W Yang, M-Y Hua, H-L Liu, C-Y Huang, K-C Wei, “Potential of magnetic nanoparticles for targeted drug delivery,” Nanotechnology, Science and Applications, Vol. 5 , 73-86, 2012
H-W Yang, M-Y Hua, K-J Lin, S-P Wey, R-Y Tsai, S-Y Wu, Y-C Lu, H-L Liu, Tony Wu, Y-H Ma, “Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis,” International Journal of Nanomedicine, Vol. 7, 1-11, 2012
H-W Yang, M-Y Hua, K-J Lin, S-P Wey, R-Y Tsai, S-Y Wu, Y-C Lu, H-L Liu, Tony Wu, Y-H Ma, “Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis,” International Journal of Nanomedicine, Vol. 7, 1-11, 2012
H-L Liu, H-Y Hsieh, L-A Lu, C-W Kang, M-F Wu and C-Y Lin, “Low-Pressure Pulsed Focused Ultrasound with Microbubbles Promotes an Anticancer Immunological Response,” Journal of Translational Medicine, Vol. 10: 221 , 1-12, 2012
M-Y Hua**, H-L Liu**, H-W Yang, P-Y Chen, R-Y Tsai, C-Y Huang, I-C Tseng, L-A Lyu, C-C Ma, H-J Tang, T-C Yen, K-C Wei, “The effectiveness of a magnetic-nanoparticle-based delivery system for BCNU in the treatment of gliomas,” Biomaterials, Vol. 32 , 512-523, 2011
H-L Liu, M-L Li, P-H Tsui, M-S Lin, S-M Huang, and J Bai,, “An Unified Approach to Combine Temperature Estimation and Elastography for Thermal Lesion Determination in Focused Ultrasound Thermal Therapy,” Physics in Medicine and Biology, Vol. 56, 169-186, 2011
H-L Liu, Y-Y Wai, P-H Hsu, L-A Lyu, J-S Wu, C-R Shen, J-C Chen, T-C Yen, and J-J Wang, “In Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Blood–brain Barrier with Focused Ultrasound: A Magnetic Resonance Imaging Study,” Journal of Cerebral Blood Flow & Metabolism, Vol. 30, 168-177, 2010
Y-C Lin, C-C Wang, Y-Y Wai, Y-L Wan,S-H Ng, Y-L Chen, H-L Liu, J-J Wang, “Significant temporal evolution of diffusion anisotropy for evaluating of early response to radiosurgery in patients with vestibular schwannoma: findings from functional diffusion maps,” American Journal of Neuroradiology, Vol. 31, 269-274, 2010
H-L Liu, C-H Pan, C-Y Ting and M-J Hsiao, “Opening of the Blood-Brain Barrier By Low-Frequency (28-kHz) Ultrasound: A Novel Pinhole-Assisted Mechanical Scanning Device,” Ultrasound in Medicine and Biology, Vol. 36, No. 2, 325-335, 2010
H-L Liu, C-L Hsu, S-M Huang and Y-W Hsi, “Focal Beam Distortion and Treatment Planning for Transrib Focused Ultrasound Thermal Therapy: A Feasibility Study Using a Two-dimensional Ultrasound Phased Array,” Medical Physics, Vol. 37, No. 2, 848-860, 2010
H-L Liu, M-Y Hua, P-Y Chen, P-C Chu, C-H Pan, H-W Yang, C-Y Huang, J-J Wang, T-C Yen and K-C Wei,, “Blood–Brain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatment,” Radiology, Vol. 255, No. 2, 415-425, 2010
P-Y Chen**, H-L Liu**, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, L-A Lyu, H-C Tsai, S-M Chen, Y-J Lu, J-J Wang, T-C Yen, Y-H Ma, T. Wu, J-P Chen, J-I Chuang, J-W Shin, C. Hsueh, and K-C Wei, “Novel Magnetic/Ultrasound Focusing System Enhances Nanoparticle Drug Delivery for Glioma Treatment,” Neuro-oncology, Vol. 12, No. 10, 1050-1060, 2010
K-C Ju and H-L Liu, “Zero-crossing-tracking technique for noninvasively ultrasonic temperature estimation,” Journal of Ultrasound in Medicine, Vol. 29, 1607-1615, 2010
H-L Liu, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, J-S Wua, I-C Tseng, J-J Wang, T-C Yen, P-Y Chen, and K-C Wei, “Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain,” Proceedings of National Academy of Science USA, , Vol. 107, No. 34, 15205-15210, 2010
H-L Liu, S-M Huang, and M-L Li, “High frame rate ultrasound monitoring of high intensity focused ultrasound induced temperature changes: a novel asynchronous approach,” Medical Physics, Vol. 37, No. 11, 5921-5928, 2010
H-L Liu, P-H Hsu, P-J Ju, Y-Y Wai, J-C Chen, C-R Shen, T-C Yen, and J-J Wang, “Magnetic Resonance Imaging Enhanced by Superparamagnetic Iron Oxide Particles: Usefulness for Distinguishing Between Focused Ultrasound-Induced Blood-Brain Barrier Disruption and Brain Hemorrhage,” Journal of Magnetic Resonance Imaging, Vol. 29, No. 1 , 31-38, 2009
H-L Liu and C-M Hsieh, “Single-Transducer Dual-Frequency Ultrasound Generation to Enhance Acoustic Cavitation,” Ultrasononics Sonochemistry, Vol. 16, No. 3, 431-438, 2009
K-J Lin**, H-L Liu**, P-H Hsu, Y-H Chung,W-C Huang, J-C Chen, S-P Wey, T-C Yen, I-T Hsiao, “Quantitative microSPECT/CT for detecting focused ultrasound induced blood-brain barrier opening in the rat,” Nuclear Medicine and Biology, Vol. 36, No. 7, 853-867, 2009
H-L Liu, M-L Li, T-C Shih, S-M Huang, I-Y Lu, D-Y Lin, S-M Lin and K-C Ju, “Instantaneous Frequency Based Ultrasonic Temperature Estimation during Focused Ultrasound Thermal Therapy,” Ultrasound in Medicine and Biology, Vol. 35, No. 10, 1647-1661, 2009
J-J Wang, Y-Y Wai, Y-H Weng, K-K Ng, Y-Z Huang; L. Ying, H-L Liu, and C-H Wang, “Functional MRI in the assessment of cortical activation during gait-related imaginary tasks,,” Journal of Neural Transmission, Vol. 116, 1087 -1092, 2009
H-L Liu, Y-Y Wai, W-S Chen, J-C Chen, P-H Hsu, X-Y W, W-C Huang, T-C Yen, and J-J Wang, “Hemorrhage Detection during Focused-Ultrasound Induced Blood–Brain-Barrier Opening by Using Susceptibility-Weighted Magnetic Resonance Imaging,” Ultrasound in Medicine & Biology, Vol. 34, No. 4, 598-606, 2008
J-J Wang, Y-C Lin, Y-Y Wai, H-L Liu, C-P Lin, Y-Z Huang, “Visualization of the coherence of the principal diffusion orientation: an eigenvector-based approach,” Magnetic Resonance in Medicine, Vol. 59, No. 4, 764-770, 2008
H-L Liu, H-W Chen, Z-H Kuo, and W-C Huang, “Design and Experimental Evaluations of a Low-Frequency Hemispherical Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Disruption,” IEEE Transactions on Biomedical Engineering, Vol.55, No. 10, 2407-2416, 2008
H-L Liu, W-L Lin, and Y-Y Chen , “A Fast and Conformal Heating Scheme for Producing Large Thermal Lesions Using a 2-D Ultrasound Phased Array,” International Journal of Hyperthermia, Vol. 23, No. 1, 69-82, 2007
H-L Liu , T-C Shih , W-S Chen and K-C Ju, “A Novel Strategy to Increase Heating Efficiency in a Split-Focus Ultrasound Phased Array,” Medical Physics, Vol. 34, No. 7, 2957-2967, 2007
H-L Liu, H Chang, W-S Chen, T-C Shih, J-K Hsiao, and W-L Lin, “Feasibility of Transrib Focused Ultrasound Thermal Ablation for Liver Tumors Using a Spherically Curved 2D Array: A Numerical Study,” Medical Physics, , Vol. 34, No. 9, 3436-3448, 2007
H-L Liu, W-S Chen, J-S Chen, T-C Shih, Y-Y Chen, and W-L Lin, “Cavitation - Enhanced Ultrasound Thermal Therapy by Combined Low- and High-Frequency Ultrasound Exposure,” Ultrasound in Medicine & Biology, Vol. 32, No. 5 , 759-767, 2006
W-S Chen, C-C Wu, S-Y Fang, H-L Liu* , “Differences in the lesion formation process between focused ultrasound and microwave ablations,” Medical Physics , Vol. 33, No. 5, 1346-1351, 2006
H-L Liu, Y-Y Chen, W-S Chen, T-C Shih, J-S Chen, and W-L Lin, “Interactions between consecutive sonications for characterizing the thermal mechanism in focused ultrasound therapy,” Ultrasound in Medicine & Biology, Vol. 32, No. 9, 1411-1421, 2006
H-L Liu, N McDannold, and K Hynynen, “Focal beam distortion and treatment planning in abdominal focused ultrasound surgery,” Medical Physics , 32, 1270-1280, Jan. 2005
Patents:
劉浩澧、崔博翔、李騏兆 , “超音波影像系統,” ，中華民國(發明)，I852356, Aug. 2024
羅敏宏、劉浩澧, “擴增實境系統及擴增實境方法,” 中華民國(發明)，I843649, May 2024
H-L Liu HC Tsai, LY Lu, KC Wei, “Neuronavigation-guided focused ultrasound system and method thereof,” India Patent No. 523109, Mar. 2024
SY Chiou, PY Chen, HL Liu, KC Wei, “Method, system, computer program product and application-specific integrated circuit for guiding surgical instrument,” US Patent No.11,806,088, Feb. 2024
廖愛禾, 王智弘, 劉浩澧, “ 無針遞送系統及其運作方法,” 中華民國(發明)，I815292, Aug. 2023
AH Liao, CH Wang, HL Liu, “Needle free delivery system and operation method thereof,” US Patent App. 17/661,564, Jul. 2023
劉浩澧, 王昱欣, 廖振淵, 郭沁儒, 王御丞, “手術導引系統,” 中華明國(發明)，108147165, Aug. 2021
H-L Liu HC Tsai, LY Lu, KC Wei, “Neuronavigation-guided focused ultrasound system and method thereof,” Israel Patent, Nov. 2020
HL Liu, MT Tsai, CK Yeh, “Imaging devices, systems, and methods of operation for acoustic-enhanced optical coherence tomography,” US Patent approved, Aug. 2020